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KMID : 0369819900200040205
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Jorunal of Korean Pharmaceutical Sciences
1990 Volume.20 No. 4 p.205 ~ p.208
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Effect of Azone on Penetration of Antiviral Agents through Hairless Mouse Skin
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최승호/Choi SH
김종갑/Kim JK
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Abstract
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1-Dodecylazacycloheptan-2-one (Azone) is a new agent that enhances the percutaneous penetration of a number of different chemicals. BVDU and FEAU were evaluated for their potential efficacy in the treatment of cutaneous herpes simplex virus infections by in vitro studies through hairless mouse skin. This study demonstrates the value of penetration enhancing agent (Azone) and the need for a predictable evaluations in the development of topical antiviral agents.
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KEYWORD
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Percutaneous penetraton, Azone, Hairless mouse skin, Herpes simplex virus (HSV), BVDU, FEAU
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